Expression upon cell types / Promoter Research Tool :

The native promoters have different strength in different tissues. In many cases, some promoter’s expression are highly upgraded in some kinds of cancer cells.

To test each promoter’s strength or to preferentially express a reporter in desired tissue types,  Gentarget developed a set of reporter lentiviruses to express a luminescence or fluorescent reporter  (firefly Luciferase, Renilla luciferase, RFP or GFP fluorescent marker) under a tissue specific promoter. Those reporter are specifically or preferably expressed in the targeted cell types which provides a great tool to labeling the specific cell types or to investigate the specific promoter strength in different tissue or cell types.

These lentivirus also express an antibiotic selection marker or another fluorescent marker under a constitutive RSV promoter which provides selection tool, serves as the internal normalization control, or as the convenient monitoring method for virus transduction efficiency. See the lentivectors’ core scheme below.

Effective Label your specific cell type:

The common report lentivirus that driven by CMV or EF1a may not able to  effectively label your cell type with a Fluorescent marker or Luciferase report. If this is the case, then use a  report lentivirus that driven by the cell type specific promoter will get your cell labelled easy and in high transduction rate.

Click into each product category’s manual for details:

1. Astrocytes Reporter;
2. B-Cell Reporter;
3. Brain-Tissue Reporter;
4. Cancer Specific Reporter;
5. Endothelial Cell Reporter;
6. Hematopoietic Cell Reporter;
7. Hepatoma Cell Reporter;
8. Kidney Cell Reporter;
9. Leukocytes Reporter;
10. Lung Tissue Reporter;
11. Macrophages Reporter;
12. Megakaryocytes Reporter;
13. Monocytes Reporter;
14. Muscle Cell Reporter;
15. Neuron Reporter;
16. Ovarian Cancer Reporter;
17. Pancreatic Cancer Reporter;
18. Prostate Cell Reporter;
19. Stem Cell Reporter;