Skip to content

For product queries: Call 1-858-265-6446 or email at info@gentarget.com

| Login / Register | 0 items | $0.00

gentarget inc.

7930 Arjons Drive, Suite B
San Diego, CA 92126
United States

  • Home
  • Products
    • Premade Lentivirus
      • cDNA (ORF) Expression
      • Luciferases Lentivirus
      • Fluorescent Markers
      • Sub-cellular Imaging
      • Nano-Lantern Imaging
      • Cytoskeleton Imaging
      • Unstable GFP
      • near-infrared RFP
      • Fluorescent fusion
      • CRE recombinase
      • CRE, Flp ColorSwtich
      • SEAP Reporter
      • Tet Repressor
      • rtTA Expression
      • lacZ Enzyme
      • iPS stem cell factors
      • Other enzyme
    • Premade AAV Virus
    • Premade Adenovirus
      • Common Markers & Enzymes
      • GFP CFP YFP RFP BFP & Controls
      • iPS Stem Cell Factors
      • ORF Expression
    • Pathway Reporter
      • Androgen Pathway
      • Antioxidant Pathway
      • ATF6 Pathway
      • C/EBP Pathway
      • CD44CR1 Pathway
      • c-Myc Pathway
      • CREB (cAMP-PKA) Pathway
      • E2F Pathway
      • EGR1 Promoter Pathway
      • Estrogen Receptor Pathway
      • FOXO Pathway
      • GATA Pathway
      • Glucocorticoid Pathway
      • Hedgehog Pathway
      • HNF4 Pathway
      • Hypoxia Pathway
      • IRF Pathway
      • JAK-STAT Pathway
      • JNK / AP1 Pathway
      • MAPK/ERK Pathway
      • MEF2 Pathway
      • MTF1 Pathway
      • NFAT Pathway
      • Notch Signal Pathway
      • NFκB Pathway
      • PPAR Pathway
      • Progesterone Pathway
      • RAR Pathway
      • STAT3 Pathway
      • TGF-β Pathway
      • TP53 Pathway
      • Wnt Signal pathway
      • XBP1 Pathway
      • Blue light inducible reporter
      • Heat inducible expression
      • Mitochondrial pH-sensitive probe
      • Signal Pathway Control
    • Cell Immortalization
      • hTERT Expression
      • SV40 Large T antigen
      • Knockdown P53 shRNA Lentivirus
      • Other Immortalization Factors
    • CARs and TCRs
      • CAR-T Lentivirus
      • TCR Lentivirus
      • Cell Antigens & Receptors
    • CRISPR Gene Editing
      • Cas9 Expression
      • Epigenomic: CRISPRi and CRISPRa
      • gRNA Lentivirus
      • CRISPR Repair and KnockIn
      • CRISPR KnockOut
    • Stable cell lines
      • Assay Cell Lines
      • Luciferase cells
      • Fluorescent cells
      • CRE and Flp reporting cells
      • CRE Expression Cells
      • CRISPR ready cell lines
      • TetR stable cells
      • rtTA stable cells
      • Inducible expression cell lines
      • Ion Channel cells
      • LacZ stable cells
      • Other stable cells
    • Cell-Specific Reporter
      • Astrocytes Report
      • B-Cell Reporter
      • Brain Cell Report
      • Cancer Specific Report
      • Endothelial Cell Report
      • Hematopoietic Cell Report
      • Hepatoma Cell Report
      • Kidney Cell Report
      • Leukocytes Report
      • Lung Tissue Report
      • Macrophages Report
      • Megakaryocytes Report
      • Monocytes Report
      • Muscle Cell Report
      • Neuron Report
      • Ovarian Cancer Report
      • Pancreatic Cancer Report
      • Prostate Cell Report
      • Stem Cell Report
    • Infectious Antigens
      • Viral Antigens
    • Virus Like Particles (VLP)
    • Non-integrating LV
    • shRNA lentivirus
      • Validated shRNA Lentivirus
      • Customized shRNA
    • microRNA lentivirus
    • anti miRNA lentivirus
    • Lentivectors
      • CRISPR gRNA lentivectors
      • shRNA Lentivectors
      • Promoter-less Lentivectors
      • Lentivirus Packaging plasmids
    • Control lentivirus
    • Ultra titer lentivirus
    • Eco PCR Cloning Kits
    • Reagents for Lentivirus
  • Services
    • Lentivirus Service
    • Customized Stable Cell Lines
    • Fusion In Vivo PCR Cloning
    • Protein Expression
    • Antibody Cloning and Expression
  • Support
    • Product citations
    • Technology
      • Optional Inducible Lentiviral System
      • SureTiter™ Lentiviral System
      • Enhanced super CMV promoter
      • InTag™ trans-membrane proteins
      • Fusion in vivo, Eco™ PCR Cloning
    • Protocols
    • MSDS Files
    • Promotion
    • Product Manuals
    • Vector sequences
    • Product FAQs
    • Terms
    • Useful Links
  • Distributors
  • About Us
  • Contact
  • News
Home / Premade Lentivirus / iPS stem cell factors

iPS stem cell factors

About Inducing Pluripotent Stem Cells (iPSC):

Conversion of  fully differentiated mouse or human somatic cells into embryonic-like cells (so called induced Pluripotent Stem Cells or iPSCs) has attracted enormous attention. Multiple reports have demonstrated that iPS cells can be generated by using a set of transcription factors or stem cell factors delivered via expression virus or by expressed proteins. The main stem cell factors are: OCT3/4, SOX2, NANOG, LIN28, c-Myc, and KLF4, although the combination of reprogramming factors may be slightly different. iPSCs hold the promise of curing many human diseases and accelerating stem cell research. 

Lentivirus express iPS factors:

Gentarget Provides the iPSC expression lentivirus driven by either the optional super CMV promoter or EF1α promoters, for all six human and mouse stem cell factors.

1. iPS Lentiviraus under CMV Promoter:

Those lentivirus contains either the RFP-Blasticidin or Neomycin antibiotic marker (see vector scheme below). 

iPSC factor expression schemes

These lentiviruses can be used for constitutive high expression and can also be used for tetracycline-inducible expression when a repressor regulator protein (TetR) is present.(see How etracycline-inducible expression works).

2. iPS Lentiviraus under CMV Promoter:

Those lentivirus contains either the RFP-Puromycin or Puromycin antibiotic marker (see vector scheme below). 

iPSC factor expression map

3. Four iPS factor chained Lentivirus:

Those Lentivirus express the four chained factors in a single lentivector, see its scheme below:

stem-cell-factor-expression lentivector schemes 

iPS lentiviral particles provide an easy tool to generate your own iPS cells. Gentarget’s iPS lentivirus was validated in generation of iPS cell and you can get your iPS cells in as short as in 14 days. Please refer to our validated iPS cell generation procedures. 

Gentarget’s  iPS Lentivirus includes: 

A) Human iPS factors (NANOG, OCT4, SOX2, KLF4, Myc, LIN28).

B) Mouse iPS factors (NANOG, OCT4, SOX2, KLF4, Myc, LIN28). 

C) Other potential iPS factors.

———————————————————————————————————-

iPS clone images generated using Gentarget’s iPS lentiviral particles:

ips clone image

[ Images above were provided by Dr. G. Wang in Harvard Medical School, Boston, MA 02115.]

References:

  1. Masaki Ieda, Ji-Dong Fu, et al. (2010). Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors. Cell 142, 375-386.
  2. Takahashi, K. and Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676.
  3. Yu, J., Vodyanik, M.A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J.L., Tian, S., Nie, J., Jonsdottir, G.A., Ruotti, V., Stewart, R., Slukvin, I.I., and Thomson, J.A. (2007). Induced pluripotent stem cell lines derived from human somatic cells. Science 318, 1917-1920.
  4. Park, I.H., et al., Reprogramming of human somatic cells to pluripotency with defined factors. Nature, 2008. 451(7175): p. 141-6.
  5. Shao, L., et al., Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame. Cell Res., 2009. 19(3): p. 296-306.
NameSKUPriceBuy
h Klf4 (EF1a, Puro) lentiviral particlesLVP322$650.00
h Klf4 (EF1a) (RP) lentiviral particlesLVP593$650.00
h Klf4 (Neo) Expression LentivirusLVP316$650.00
h LIN28 (EF1a, puro) lentiviral particlesLVP320$650.00
h LIN28 (EF1a) (RP) lentiviral particlesLVP591$650.00
h LIN28 (Neo) inducible particlesLVP314$650.00
h LIN28 (RFP-Bsd) inducible particlesLVP006$650.00
h MEF2C inducible lentiviral particlesLVP199$395.00
h Myc (EF1a, Puro) lentiviral particlesLVP321$650.00
h Myc (EF1a) (RP) lentiviral particlesLVP592$650.00
h Myc (Neo) inducible particlesLVP315$650.00
h Myc (RFP-Bsd) inducible particlesLVP007$650.00
h NANOG (EF1a) (puro) lentiviral particlesLVP319$650.00
h NANOG (EF1a) (RP) lentiviral particlesLVP590$650.00
h NANOG (Neo) inducible particlesLVP313$650.00
h NANOG (RFP-Bsd) inducible particlesLVP005$650.00
h OCT4 (EF1a, Puro) lentiviral particlesLVP317$650.00
h OCT4 (EF1a) (RP) lentiviral particlesLVP588$650.00
h OCT4 (Neo) inducible particlesLVP311$650.00
h OCT4 (RFP-Bsd) inducible particlesLVP003$650.00
h SOX2 (EF1a, Puro) lentiviral particlesLVP318$650.00
h SOX2 (EF1a) (RP) lentiviral particlesLVP589$650.00
h SOX2 (Neo) inducible particlesLVP312$650.00
h SOX2 (RFP-Bsd) inducible particlesLVP004$650.00
human Klf4 (RFP-Bsd) Expression LentivirusLVP008$650.00
m Klf4 (Neo) inducible particlesLVP316m$650.00
m LIN28 (Neo) inducible particlesLVP314m$650.00
m LIN28 (RFP-Bsd) inducible particlesLVP006m$650.00
m MEF2C inducible lentiviral particlesLVP270$395.00
m Mesp1 inducible lentiviral particlesLVP271$395.00
m Myc (Neo) inducible particlesLVP315m$650.00
m Myc (RFP-Bsd) inducible particlesLVP007m$650.00
m NANOG (Neo) inducible particlesLVP313m$650.00
m NANOG (RFP-Bsd) inducible particlesLVP005m$650.00
m OCT4 (Neo) inducible particlesLVP311m$650.00
m OCT4 (RFP-Bsd) inducible particlesLVP003m$650.00
m SOX2 (Neo) inducible particlesLVP312m$650.00
m Sox2 (RFP-Bsd) inducible particlesLVP004m$650.00
mouse Klf4 RFP-Bsd) Expression LentivirusLVP008m$650.00

    Cart

    Product Selection Guides

    • Luciferase Imaging
    • Cell Immortalization
    • Signal Pathway Assay
    • cDNA (ORF) Expression
    • CAR-T, TCR and More
    • CRISPR, CRISPRa, CRISPRi
    • Sub-cellular Imaging
    • Reporter Cell Lines
    • Premade Lentivirus
    • Promoter Research
    • Lentivirus & Cell Line Services

    VIEW MORE

    Stay Connected

    Online Payment Service
  • Home
  • Products
    • Premade Lentivirus
    • Premade AAV Virus
    • Premade Adenovirus
    • Pathway Reporter
    • Cell Immortalization
    • CARs and TCRs
    • CRISPR Gene Editing
    • Stable cell lines
    • Cell-Specific Reporter
    • Infectious Antigens
    • Virus Like Particles (VLP)
    • Non-integrating LV
    • shRNA lentivirus
    • microRNA lentivirus
    • anti miRNA lentivirus
    • Lentivectors
    • Control lentivirus
    • Ultra titer lentivirus
    • Eco PCR Cloning Kits
    • Reagents for Lentivirus
  • Services
    • Lentivirus Service
    • Customized Stable Cell Lines
    • Fusion In Vivo PCR Cloning
    • Protein Expression
    • Antibody Cloning and Expression
  • Support
    • Product citations
    • Technology
    • Protocols
    • MSDS Files
    • Promotion
    • Product Manuals
    • Vector sequences
    • Product FAQs
    • Terms
    • Useful Links
  • Distributors
  • About Us
  • Contact
  • News

2008 ~ ©, 2025 GenTarget Inc. All rights reserved.

Contact | Terms | View Cart

Scroll Up