COVID-19 S Protein Mutant (K417N, E484K, N501Y)-6His VLP


SKU: VLP017 Category:


COVID-19 Spike protein (S), Mutant (K417N, E484K, N501Y) Virus Like Particle was packaged in HEK293T cells using our proprietary technology. It is the replication-incompetent particles in which the native, COVID-19 S protein, Mutant (K417N, E484K, N501Y) (with 6His-tag at its C-terminal) was pseudo-typed as the lentiviral particles’ surface envelope protein.  [Note: This VLP has the Spike protein already expressed / presented at surface of lentiviral particle to mimic coronavirus. It is not used as lentivirus for over-expression of the Spike protein. For over-expressing COVID-19 S protein, please use lentivirus product, CAT#: LVP1438.]

To maintain the particle structure, the VLP was packaged with a non-sense sequence (Null) as the particle’s virion genomic material.  this VLP will also bind onto to the cells that express the COVID-19 S protein receptor (such as ACE2).


The S protein mutant was assembled as surface antigens for use in the development of COVID-19 diagnostics and in vaccine development and other validation assays for COVID-19 coronavirus. This VLP can be detected by anti-C-terminal 6His-tag antibody because the S protein was tagged by C-term 6His-tag.

The VLP’s titer was measured via ELISA P24 assay. Every single particle has assembled many S protein molecular on its surface. See more details in Product Manual.

Amount: 200ul/vial at 1×108 VP/ml.

CAT#: VLP017


Front Bioeng. Biotechnol. 30 July 2020; Ruodan Xu et al. Construction of SARS-CoV-2 Virus-Like Particles..