Transformed from HEK293 cells by lentiviral system, this cell line expresses human KCNN4 gene (NM_002250.2).
KCNN4 was constitutively expressed under an enhanced EF1a promoter. The RFP-Blasticidin marker was expressed under Rsv promoter. The cell constitutively express both KCNN4 and RFP.
The KCNN4 protein is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
Sold at: 1 vial x (2 x 106 cells)/vial, see details in Product Manual.