Human B-lymphocyte antigen CD19 gene is a transmembrane protein, also known as CD19 molecule, B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12 and CVID3. CD19 is expressed in all B lineage cells. CD19 is widely expressed during all phases of B cell development until terminal differentiation into plasma cells. It is a biomarker for B lymphocyte development, lymphoma diagnosis and can be utilized as a target for leukemia immunotherapies, such as the target cells for Anti-CD19 CAR T cell killing assay.
This cell line is transformed from CHO K1 cell line (an adhesive cell line, derived from a female Chinese hamster’s ovary), expressing human B-lymphocyte antigen CD19 (transcript variant 1) with codon sequence perfectly match to the CD region of human CD19, transcript variant 1 (GeneBank# NM_001178098), under the enhanced CMV promoter (suCMV). The following cassette was verified integrated into cell line’s genome:
Strong Green fluorescent signal was visualized in every single cell under fluorescent microscope (Ex ~490nm / Em ~525nm), see sample image below:
see details in Product Manual.
Sold at: 1 vial x (2 x 106 cells)/vial, in stock, shipped in a dry-ice package.