This cell line is transformed from HEK293T stable cell line via lentiviral system, over-expressing human angiotensin-converting enzyme 2 (ACE2) gene (NM_021804), under the enhanced EF1a promoter. A RFP-Blasticidin fusion dual marker was expressed under RSV promoter (see the integrated expression cassette below). This cell line can be used for in vitro screening and characterization of antibodies, vaccines, or drug candidates against SARS-CoV, COVID-19 coronavirus.
ACE2 receptor may play roles in the regulation of renal and cardiovascular function, as well as fertility. It is mainly expressed in vascular endothelial cells. The ACE2 receptor is the entry point into human cells for some coronaviruses, including the SARS virus and COVID-19 coronavirus (SARS-CoV-2).
Sold at: 1 vial x (>2 x 106 cells)/vial, Click Product Manual for more details.