CRISPR based epigenomic expression regulation

CRISPR/Cas9 gene editing has emerged as a powerful tool for making genomic sequence changes. However, concerns surrounding off-target effects and undesired alterations in the genome have been raised. To address these challenges, a mutant form of Cas9 known as dCas9 (deficient Cas9 or Dead Cas9) has been developed. Unlike Cas9, dCas9 lacks the ability to Read More >