TCR Lentivirus

1. Understanding TCRs

T cell receptors (TCRs) are a group of proteins found on T cells that bind to certain antigens (proteins) found on abnormal cells, cancer cells, cells from other organisms, and cells infected with a virus or another microorganism. This interaction causes the T cells to attack these cells and helps the body fight infection, cancer, or other diseases.

Unlike CAR-T cell therapy, which involves engineering synthetic receptors, TCR cell therapy utilizes naturally occurring TCRs that recognize specific antigens.

TCR engages HLA-peptide complexes and needs to be matched to the patient’s haplotype. CARs however do not require antigen processing and presentation by HLA. CARs are limited to recognizing cell surface antigens, whereas TCRs recognize both cell surface and intracellular proteins.

2. Gentarget’s CAR lentivirus Structure

Significant progress have been made in well-characterize  tumor antigens, such as MART-1, NY-ESO1, α-GalCer and more. TCR consists of T cell receptor α (TCRα) and β (TCRβ) chains, linked by a disulfide bond. Gentarget’s TCR Lentivirus product line uses Vα/Vβ regions mediated by F2A element, allowing the formation of TCR structure on the T cell surface. These Lentivirus products provide convenient tools for modifying T cells in anti-cancer research.

See products listed below, or click TCR-Lentivirus to see all products.

We also provide services to generate your desired TCR construct / lentivirus. Please contact us for service inquiries. Please see also our CARs Lentivirus page.