Skip to content

For product queries: Call 1-858-265-6446 or email at info@gentarget.com

| Login / Register | 0 items | $0.00

gentarget inc.

7930 Arjons Drive, Suite B
San Diego, CA 92126
United States

  • Home
  • Products
    • Premade Lentivirus
      • cDNA (ORF) Expression
      • Luciferases Lentivirus
      • Fluorescent Markers
      • Sub-cellular Imaging
      • Nano-Lantern Imaging
      • Cytoskeleton Imaging
      • Unstable GFP
      • near-infrared RFP
      • Fluorescent fusion
      • CRE recombinase
      • CRE, Flp ColorSwtich
      • SEAP Reporter
      • Tet Repressor
      • rtTA Expression
      • lacZ Enzyme
      • iPS stem cell factors
      • Other enzyme
    • Premade AAV Virus
    • Premade Adenovirus
      • Common Markers & Enzymes
      • GFP CFP YFP RFP BFP & Controls
      • iPS Stem Cell Factors
      • ORF Expression
    • Pathway Reporter
      • Androgen Pathway
      • Antioxidant Pathway
      • ATF6 Pathway
      • C/EBP Pathway
      • CD44CR1 Pathway
      • c-Myc Pathway
      • CREB (cAMP-PKA) Pathway
      • E2F Pathway
      • EGR1 Promoter Pathway
      • Estrogen Receptor Pathway
      • FOXO Pathway
      • GATA Pathway
      • Glucocorticoid Pathway
      • Hedgehog Pathway
      • HNF4 Pathway
      • Hypoxia Pathway
      • IRF Pathway
      • JAK-STAT Pathway
      • JNK / AP1 Pathway
      • MAPK/ERK Pathway
      • MEF2 Pathway
      • MTF1 Pathway
      • NFAT Pathway
      • Notch Signal Pathway
      • NFκB Pathway
      • PPAR Pathway
      • Progesterone Pathway
      • RAR Pathway
      • STAT3 Pathway
      • TGF-β Pathway
      • TP53 Pathway
      • Wnt Signal pathway
      • XBP1 Pathway
      • Blue light inducible reporter
      • Heat inducible expression
      • Mitochondrial pH-sensitive probe
      • Signal Pathway Control
    • Cell Immortalization
      • hTERT Expression
      • SV40 Large T antigen
      • Knockdown P53 shRNA Lentivirus
      • Other Immortalization Factors
    • CARs and TCRs
      • CAR-T Lentivirus
      • TCR Lentivirus
      • Cell Antigens & Receptors
    • CRISPR Gene Editing
      • Cas9 Expression
      • Epigenomic: CRISPRi and CRISPRa
      • gRNA Lentivirus
      • CRISPR Repair and KnockIn
      • CRISPR KnockOut
    • Stable cell lines
      • Assay Cell Lines
      • Luciferase cells
      • Fluorescent cells
      • CRE and Flp reporting cells
      • CRE Expression Cells
      • CRISPR ready cell lines
      • TetR stable cells
      • rtTA stable cells
      • Inducible expression cell lines
      • Ion Channel cells
      • LacZ stable cells
      • Other stable cells
    • Cell-Specific Reporter
      • Astrocytes Report
      • B-Cell Reporter
      • Brain Cell Report
      • Cancer Specific Report
      • Endothelial Cell Report
      • Hematopoietic Cell Report
      • Hepatoma Cell Report
      • Kidney Cell Report
      • Leukocytes Report
      • Lung Tissue Report
      • Macrophages Report
      • Megakaryocytes Report
      • Monocytes Report
      • Muscle Cell Report
      • Neuron Report
      • Ovarian Cancer Report
      • Pancreatic Cancer Report
      • Prostate Cell Report
      • Stem Cell Report
    • Infectious Antigens
      • Viral Antigens
    • Virus Like Particles (VLP)
    • Non-integrating LV
    • shRNA lentivirus
      • Validated shRNA Lentivirus
      • Customized shRNA
    • microRNA lentivirus
    • anti miRNA lentivirus
    • Lentivectors
      • CRISPR gRNA lentivectors
      • shRNA Lentivectors
      • Promoter-less Lentivectors
      • Lentivirus Packaging plasmids
    • Control lentivirus
    • Ultra titer lentivirus
    • Eco PCR Cloning Kits
    • Reagents for Lentivirus
  • Services
    • Lentivirus Service
    • Customized Stable Cell Lines
    • Fusion In Vivo PCR Cloning
    • Protein Expression
    • Antibody Cloning and Expression
  • Support
    • Product citations
    • Technology
      • Optional Inducible Lentiviral System
      • SureTiter™ Lentiviral System
      • Enhanced super CMV promoter
      • InTag™ trans-membrane proteins
      • Fusion in vivo, Eco™ PCR Cloning
    • Protocols
    • MSDS Files
    • Promotion
    • Product Manuals
    • Vector sequences
    • Product FAQs
    • Terms
    • Useful Links
  • Distributors
  • About Us
  • Contact
  • News
Home / CARs and TCRs

CARs and TCRs

virus ball

GenTarget’s Products for ImmunoOncology / Immunotherapy Research:

Gentarget is dedicated to support the ImmunoOncology or Immunotherapy research field, by providing comprehensive product lines, see product categories listed below. All products are provided for Research Use Only.

  1. Targeted CAR, TCR, TAC lentivirus;
  2. Premade Assay Cell Lines for T-cell targeted killing assay and other cell-based assays;
  3. Premade over-expression lentivirus products for the immune response targets; Cell surface antigens (CDs); immune checkpoint / Receptors;
  4. CRISPR gene Repair and knock-IN lentivirus;
  5. CRISPR knockout lentivirus;

What is Immunotherapy:

Immunotherapy is an emerging cancer treatment roughly including two aspects: (1) deliver the genetically modified T cells to patients to kill cancer cells; (2) promote the immune responses for cancer suppression.

The advantages of Immunotherapy are: (1) the targeted cancer cell treatment can be achieved because of immune system precision. (2) immunotherapy is live, continuous, and dynamical treatment and memorized so it can be self-adjusted, long-term treatment corresponding to the cancer development;(3) T- cell therapy can kill solid tumors, which are difficult to treat with other immune therapies.

How immunotherapy works:

Human immune system is activated when any “foreign substances” are encountered.  The immune response attacks and destroys anything containing Foreign substances, like cancer cells. The principle of immunotherapy is:

  1. activating, training, or engineering patient’s immune cells in a lab and reintroducing them into the same patient, to find and attack cancer cells;
  2. Stimulating, or boosting the natural defenses of your immune system so it works harder or smarter to find and attack cancer cells;

The main types of immunotherapy:

  1. checkpoint inhibitors: Immune checkpoints are molecules on certain immune cells that need to be activated (or inactivated) to start an immune response. Cancer cells sometimes find ways to use these checkpoints to avoid being attacked by the immune system. Checkpoint inhibitors are drugs or antibodies to block the signaling pathway that suppresses the immune system, which enables immune effector cells to attack cancer cells more aggressively. It acts at the activation of immune response, not directly on cancer cells.
  2. Genetically Engineered T Cells: Thistreatmentis directly act on cancer cells including several methods:(1) Expressing a CAR (Chimeric Antigen Receptor) that is composed of an intracellular signaling domain and the linked extracellular domain derived from a tumor-specific antibody. The tumor-specific receptor guilds the T cells to attack specific tumor types. The killing depends upon the desired signaling pathway. The ideal cases are the CAR target only present on tumor cells, not normal cells; (2)The T cell was modified at its endogenous TCR (T Cell Receptor ) gene to recognize a tumor-specific antigen, which activates the native T cell killing signal pathway. The TCR method has less side-effects than CAR does who elevates an un-nature signal level resulted in the severe Cytokine release syndrome side-effect; (3)coupled with a tumor-specific antigen binding domain (TAC: T-cell Antigen Coupler),(4)combined engineered T cells with the knockout of endogenous TCR with insertion of an anti-cancer factor so that the T cell can provide as the allogeneic  adoptive anti-cancer treatment;
  3. Cytokines: Cytokines encompass a variety of protein families including interleukins, interferons, growth factors, tumor necrosis factors, and colony-stimulating factors. Cytokines act on every phase of the cancer immunity cycle, improving antigen priming, inflammation and hematopoiesis, and other specific physiological response to external stimuli including cancer. cytokines can stimulate the immune cells to attack cancer.
  4. Others: cancer immunotherapy has many other types of treatment, including Monoclonal antibodies (raised from cancel specific antigen, attack a very specific part of cancer cell); Cancer vaccines; Oncolytic virus, enrich or enhance the NK cell, Macrophage cell and so on.
NameSKUPriceBuy
Anti-BCMA-ScFv-4-1BB-CD3ζLVP1647$790.00
Anti-BCMA-ScFv-4-1BB-CD3ζ (GFP-Puro)LVP1649$790.00
Anti-BCMA-ScFv-4-1BB-CD3ζ (Puro)LVP1648$790.00
Anti-BCMA-ScFv-CD28-CD3ζLVP1650$790.00
Anti-BCMA-ScFv-CD28-CD3ζ (GFP-Puro)LVP1652$790.00
Anti-BCMA-ScFv-CD28-CD3ζ (Puro)LVP1651$790.00
Anti-CD19_CD20-ScFv-4-1BB-CD3ζLVP1641$790.00
Anti-CD19_CD20-ScFv-4-1BB-CD3ζ (GFP-Puro)LVP1643$790.00
Anti-CD19_CD20-ScFv-4-1BB-CD3ζ (Puro)LVP1642$790.00
Anti-CD19_CD20-ScFv-CD28-CD3ζLVP1644$790.00
Anti-CD19_CD20-ScFv-CD28-CD3ζ (GFP-Puro)LVP1646$790.00
Anti-CD19_CD20-ScFv-CD28-CD3ζ (Puro)LVP1645$790.00
Anti-CD19-ScFv-4-1BB-CD3ζLVP1444$650.00
Anti-CD19-ScFv-4-1BB-CD3ζ (Bsd)LVP1441$650.00
Anti-CD19-ScFv-4-1BB-CD3ζ (GFP-Puro)LVP1442$650.00
Anti-CD19-ScFv-4-1BB-CD3ζ (Puro)LVP1440$650.00
Anti-CD19-ScFv-4-1BB-CD3ζ (RFP-Puro)LVP1443$650.00
Anti-CD19-ScFv-CD28-CD3ζLVP1449$650.00
Anti-CD19-ScFv-CD28-CD3ζ (Bsd)LVP1446$650.00
Anti-CD19-ScFv-CD28-CD3ζ (GFP-Puro)LVP1447$650.00
Anti-CD19-ScFv-CD28-CD3ζ (Puro)LVP1445$650.00
Anti-CD19-ScFv-CD28-CD3ζ (RFP-Puro)LVP1448$650.00
Anti-CD22-ScFv-CD28-CD3ζLVP1662$790.00
Anti-CD22-ScFv-CD28-CD3ζ (GFP-Puro)LVP1664$790.00
Anti-CD22-ScFv-CD28-CD3ζ (Puro)LVP1663$790.00
Anti-h HLA-A2-ScFv-4-1BB-CD3ζ (GFP-Puro)LVP1667$790.00
Anti-h CD22-ScFv-4-1BB-CD3ζLVP1659$790.00
Anti-h CD22-ScFv-4-1BB-CD3ζ (GFP-Puro)LVP1661$790.00
Anti-h CD22-ScFv-4-1BB-CD3ζ (Puro)LVP1660$790.00
Anti-h HER2-ScFv-4-1BB-CD3ζLVP1653$790.00
Anti-h HER2-ScFv-4-1BB-CD3ζ (GFP-Puro)LVP1655$790.00
Anti-h HER2-ScFv-4-1BB-CD3ζ (Puro)LVP1654$790.00
Anti-h HLA-A2-ScFv-4-1BB-CD3ζ (No marker)LVP1665$790.00
Anti-h HLA-A2-ScFv-4-1BB-CD3ζ (Puro)LVP1666$790.00
Anti-HER2-ScFv-CD28-CD3ζLVP1656$790.00
Anti-HER2-ScFv-CD28-CD3ζ (GFP-Puro)LVP1658$790.00
Anti-HER2-ScFv-CD28-CD3ζ (Puro)LVP1657$790.00
Anti-HLA-A2-ScFv-CD28-CD3ζLVP1668$790.00
Anti-HLA-A2-ScFv-CD28-CD3ζ (GFP-Puro)LVP1670$790.00
Anti-HLA-A2-ScFv-CD28-CD3ζ (Puro)LVP1669$790.00
Anti-TGFβ-ScFv-4-1BB-CD3ζ (GFP-Puro)LVP1673$790.00
Anti-TGFβ-ScFv-4-1BB-CD3ζ (No marker)LVP1671$790.00
Anti-TGFβ-ScFv-4-1BB-CD3ζ (Puro)LVP1672$790.00
Anti-TGFβ-ScFv-CD28-CD3ζLVP1674$790.00
Anti-TGFβ-ScFv-CD28-CD3ζ (GFP-Puro)LVP1676$790.00
Anti-TGFβ-ScFv-CD28-CD3ζ (Puro)LVP1675$790.00
CAR negative control: 4-1BB-CD3ζ (GFP-Puro)CAR-Ctr7$395.00
CAR negative control: 4-1BB-CD3ζ (No Marker)CAR-Ctr5$395.00
CAR negative control: 4-1BB-CD3ζ (Puro)CAR-Ctr1$395.00
CAR negative control: Anti-CD19-ScFv-4-1BB (Puro)CAR-Ctr2$395.00
CAR negative control: Anti-CD19-ScFv-CD28 (Puro)CAR-Ctr4$395.00
CAR negative control: CD28-CD3ζ (GFP-Puro)CAR-Ctr8$395.00
CAR negative control: CD28-CD3ζ (No Marker)CAR-Ctr6$395.00
CAR negative control: CD28-CD3ζ (Puro)CAR-Ctr3$395.00
h CD19 (EF1a, Puro) Expression, Concentrated LentivirusLVP1451$650.00
h CD26 (EF1a, Puro) Expression, Concentrated LentivirusLVP1452$650.00
h PDL1 (EF1a, Puro) Expression, Concentrated LentivirusLVP1450$650.00
TCR-(CD1d-α-GalCer) (Clone NKT15) (GFP-Puro)LVP1688$790.00
TCR-(CD1d-α-GalCer) (Clone NKT15) (No Marker)LVP1686$790.00
TCR-(CD1d-α-GalCer) (Clone NKT15) (Puro)LVP1687$790.00
TCR-(EB specific pMH) (GFP-Puro)LVP1691$790.00
TCR-(EB specific pMH) (No Marker)LVP1689$790.00
TCR-(EB specific pMH) (Puro)LVP1690$790.00
TCR-(EB specific pMH)-CXCR3 (GFP-Puro)LVP1694$790.00
TCR-(EB specific pMH)-CXCR3 (Puro)LVP1693$790.00
TCR-(EB specific pMH)-CXCR3(No Selection)LVP1692$790.00
TCR-(MART-1) #1 (Clone DMF5) (GFP-Puro)LVP1679$790.00
TCR-(MART-1) #1 (Clone DMF5) (No Marker)LVP1677$790.00
TCR-(MART-1) #1 (Clone DMF5) (Puro)LVP1678$790.00
TCR-(MART-1) #1 (peptide 2) (GFP-Puro)LVP1682$790.00
TCR-(MART-1) #1 (peptide 2) (Puro)LVP1681$790.00
TCR-(MART-1) #2 (No Marker)LVP1680$790.00
TCR-(NY-ESO1) (Clone 1G4) (GFP-Puro)LVP1685$790.00
TCR-(NY-ESO1) (Clone 1G4) (No Marker)LVP1683$790.00
TCR-(NY-ESO1) (Clone 1G4) (Puro)LVP1684$790.00

    Cart

    Product Selection Guides

    • Luciferase Imaging
    • Cell Immortalization
    • Signal Pathway Assay
    • cDNA (ORF) Expression
    • CAR-T, TCR and More
    • CRISPR, CRISPRa, CRISPRi
    • Sub-cellular Imaging
    • Reporter Cell Lines
    • Premade Lentivirus
    • Promoter Research
    • Lentivirus & Cell Line Services

    VIEW MORE

    Stay Connected

    Online Payment Service
  • Home
  • Products
    • Premade Lentivirus
    • Premade AAV Virus
    • Premade Adenovirus
    • Pathway Reporter
    • Cell Immortalization
    • CARs and TCRs
    • CRISPR Gene Editing
    • Stable cell lines
    • Cell-Specific Reporter
    • Infectious Antigens
    • Virus Like Particles (VLP)
    • Non-integrating LV
    • shRNA lentivirus
    • microRNA lentivirus
    • anti miRNA lentivirus
    • Lentivectors
    • Control lentivirus
    • Ultra titer lentivirus
    • Eco PCR Cloning Kits
    • Reagents for Lentivirus
  • Services
    • Lentivirus Service
    • Customized Stable Cell Lines
    • Fusion In Vivo PCR Cloning
    • Protein Expression
    • Antibody Cloning and Expression
  • Support
    • Product citations
    • Technology
    • Protocols
    • MSDS Files
    • Promotion
    • Product Manuals
    • Vector sequences
    • Product FAQs
    • Terms
    • Useful Links
  • Distributors
  • About Us
  • Contact
  • News

2008 ~ ©, 2025 GenTarget Inc. All rights reserved.

Contact | Terms | View Cart

Scroll Up